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Adenylyl cyclases (ACs) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Adenylyl cyclase, E.C. 4.6.1.1, converts ATP to cyclic AMP and pyrophosphate. Mammalian membrane-delimited adenylyl cyclases (nomenclature as approved by the NC-IUPHAR Subcommittee on Adenylyl cyclases [10]) are typically made up of two clusters of six TM domains separating two intracellular, overlapping catalytic domains that are the target for the nonselective activators Gαs (the stimulatory G protein α subunit) and forskolin (except AC9, [26]). Adenosine and its derivatives (e.g. 2',5'-dideoxyadenosine), acting through the P-site,are inhibitors of adenylyl cyclase activity [33]. Four families of membranous adenylyl cyclase are distinguishable: calmodulin (CALM2, CALM3, CALM1, P62158)-stimulated (AC1, AC3 and AC8), Ca2+- and Gβγ-inhibitable (AC5, AC6 and AC9), Gβγ-stimulated and Ca2+-insensitive (AC2, AC4 and AC7), and forskolin-insensitive (AC9) forms. A soluble adenylyl cyclase (AC10) lacks membrane spanning regions and is insensitive to G proteins.It functions as a cytoplasmic bicarbonate (pH-insensitive) sensor [6].

Enzymes

1285
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AC1 (adenylyl cyclase 1) C Show summary »

AC2 (adenylyl cyclase 2) C Show summary »

AC3 (adenylyl cyclase 3) C Show summary »

AC4 (adenylyl cyclase 4) C Show summary »

AC5 (adenylyl cyclase 5) C Show summary »

AC6 (adenylyl cyclase 6) C Show summary »

AC7 (adenylyl cyclase 7) C Show summary »

AC8 (adenylyl cyclase 8) C Show summary »


Target Id 1285
Nomenclature adenylyl cyclase 8
Common abbreviation AC8
Previous and unofficial names AC VIII | ADCY3 | ADCY8 | adenylate cyclase 8 | adenylate cyclase 8 (brain) | ca(2+)/calmodulin-activated adenylyl cyclase
Genes ADCY8 (Hs), Adcy8 (Mm), Adcy8 (Rn)
Ensembl ID ENSG00000155897 (Hs), ENSMUSG00000022376 (Mm), ENSRNOG00000004890 (Rn)
UniProtKB AC P40145 (Hs), P97490 (Mm), P40146 (Rn)
EC number
4.6.1.1
Endogenous activators calmodulin (CALM2, CALM3, CALM1, P62158)  [4]
Endogenous inhibitors PKA-evoked phosphorylation  [36]

AC9 (adenylyl cyclase 9) C Show summary »

AC10 (adenylyl cyclase 10) C Show summary »

Comments

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.