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CYP3 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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CYP1, 2 and 3 family enzymes are involved in the biotransformation of xenobiotics, including clinically used drugs. CYP3A4 is the major enzyme involved in drug metabolism by the liver.


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CYP3A4 C Show summary » More detailed page go icon to follow link

CYP3A5 C Show summary »

Target Id 1338
Nomenclature CYP3A5
Previous and unofficial names cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5 | cytochrome P450, family 3, subfamily A, polypeptide 5
Genes CYP3A5 (Hs)
Ensembl ID ENSG00000106258 (Hs)
UniProtKB AC P20815 (Hs)
EC number
ritonavir pKi 6.9 [2]
Comment CYP3A5 is expressed extrahepatically, including in the small intestine. It has overlapping substrate specificity with CYP3A4 [1,10].

CYP3A7 C Show summary »

CYP3A43 C Show summary »


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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.