Top ▲

CYP24, CYP26 and CYP27 families C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

« Hide

CYP24s deactivate vitamin D metabolites and CYP27s are required for the biosynthesis of vitamin D from cholesterol. CYP26 enzymes metabolise excess all-trans-retinol to limit toxicity.


Click here for help

Vitamin D3 24-hydroxylase (CYP24A1) C Show summary »

Target Id 1365
Nomenclature CYP24A1
Common abbreviation Vitamin D3 24-hydroxylase
Previous and unofficial names 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | 25-hydroxyvitamin D3 24-hydroxylase | cytochrome P450 24A1 | cytochrome P450, subfamily 24 | cytochrome P450, family 24, subfamily A, polypeptide 1 | cytochrome P450, family 24, subfamily a, polypeptide 1 | cytochrome P450
Genes CYP24A1 (Hs), Cyp24a1 (Mm), Cyp24a1 (Rn)
Ensembl ID ENSG00000019186 (Hs), ENSMUSG00000038567 (Mm), ENSRNOG00000013062 (Rn)
UniProtKB AC Q07973 (Hs), Q64441 (Mm), Q09128 (Rn)
EC number
CTA091 pIC50 8.2 [5]
lunacalcipol pIC50 7.6 [5]
compound 4d [PMID: 20655626] pIC50 4.8 [1]
Comment Converts 1,25-dihydroxyvitamin D3 (calcitriol) to 1α,24R,25-trihydroxyvitamin D3.

CYP26A1 C Show summary » More detailed page go icon to follow link

CYP26B1 C Show summary »

CYP26C1 C Show summary »

Sterol 27-hydroxylase (CYP27A1) C Show summary »

25-Hydroxyvitamin D 1-alpha-hydroxylase (CYP27B1) C Show summary »

CYP27C1 C Show summary »


Click here for help

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.