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CYP24, CYP26 and CYP27 families C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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CYP24s deactivate vitamin D metabolites and CYP27s are required for the biosynthesis of vitamin D from cholesterol. CYP26 enzymes metabolise excess all-trans-retinol to limit toxicity.


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Vitamin D3 24-hydroxylase (CYP24A1) C Show summary »

CYP26A1 C Show summary » More detailed page go icon to follow link

CYP26B1 C Show summary »

CYP26C1 C Show summary »

Target Id 1368
Nomenclature CYP26C1
Previous and unofficial names cytochrome P450 | cytochrome P450, family 26, subfamily c, polypeptide 1
Genes CYP26C1 (Hs), Cyp26c1 (Mm), Cyp26c1 (Rn)
Ensembl ID ENSG00000187553 (Hs), ENSMUSG00000062432 (Mm), ENSRNOG00000030698 (Rn)
UniProtKB AC Q6V0L0 (Hs)
EC number
Comment Converts retinoic acid to 4-hydroxyretinoic acid [6].

Sterol 27-hydroxylase (CYP27A1) C Show summary »

25-Hydroxyvitamin D 1-alpha-hydroxylase (CYP27B1) C Show summary »

CYP27C1 C Show summary »


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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.