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CYP24, CYP26 and CYP27 families C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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CYP24s deactivate vitamin D metabolites and CYP27s are required for the biosynthesis of vitamin D from cholesterol. CYP26 enzymes metabolise excess all-trans-retinol to limit toxicity.

Enzymes

1369
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Vitamin D3 24-hydroxylase (CYP24A1) C Show summary »

CYP26A1 C Show summary » More detailed page go icon to follow link

CYP26B1 C Show summary »

CYP26C1 C Show summary »

Sterol 27-hydroxylase (CYP27A1) C Show summary »


Target Id 1369
Nomenclature CYP27A1
Common abbreviation Sterol 27-hydroxylase
Previous and unofficial names 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase | sterol 26-hydroxylase, mitochondrial | vitamin D(3) 25-hydroxylase | cholesterol 27 hydroxylase | cytochrome P450, family 27, subfamily A, polypeptide 1 | cytochrome P450
Genes CYP27A1 (Hs), Cyp27a1 (Mm), Cyp27a1 (Rn)
Ensembl ID ENSG00000135929 (Hs), ENSMUSG00000026170 (Mm), ENSRNOG00000017188 (Rn)
UniProtKB AC Q02318 (Hs), Q9DBG1 (Mm), P17178 (Rn)
EC number
1.14.15.15
Inhibitors
compound 4d [PMID: 20655626] pIC50 7.2 [1]
CTA091 pIC50 <6.0 [3]
Comment Converts cholesterol to 27-hydroxycholesterol.

25-Hydroxyvitamin D 1-alpha-hydroxylase (CYP27B1) C Show summary »

CYP27C1 C Show summary »

References

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.