Top ▲

CYP24, CYP26 and CYP27 families C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

« Hide

CYP24s deactivate vitamin D metabolites and CYP27s are required for the biosynthesis of vitamin D from cholesterol. CYP26 enzymes metabolise excess all-trans-retinol to limit toxicity.


Click here for help

Vitamin D3 24-hydroxylase (CYP24A1) C Show summary »

CYP26A1 C Show summary » More detailed page go icon to follow link

CYP26B1 C Show summary »

CYP26C1 C Show summary »

Sterol 27-hydroxylase (CYP27A1) C Show summary »

Target Id 1369
Nomenclature CYP27A1
Common abbreviation Sterol 27-hydroxylase
Previous and unofficial names 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase | sterol 26-hydroxylase, mitochondrial | vitamin D(3) 25-hydroxylase | cholesterol 27 hydroxylase | cytochrome P450, family 27, subfamily A, polypeptide 1 | cytochrome P450
Genes CYP27A1 (Hs), Cyp27a1 (Mm), Cyp27a1 (Rn)
Ensembl ID ENSG00000135929 (Hs), ENSMUSG00000026170 (Mm), ENSRNOG00000017188 (Rn)
UniProtKB AC Q02318 (Hs), Q9DBG1 (Mm), P17178 (Rn)
EC number
compound 4d [PMID: 20655626] pIC50 7.2 [1]
CTA091 pIC50 <6.0 [3]
Comment Converts cholesterol to 27-hydroxycholesterol.

25-Hydroxyvitamin D 1-alpha-hydroxylase (CYP27B1) C Show summary »

CYP27C1 C Show summary »


Click here for help

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.