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CYP24, CYP26 and CYP27 families C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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CYP24s deactivate vitamin D metabolites and CYP27s are required for the biosynthesis of vitamin D from cholesterol. CYP26 enzymes metabolise excess all-trans-retinol to limit toxicity.


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Vitamin D3 24-hydroxylase (CYP24A1) C Show summary »

CYP26A1 C Show summary » More detailed page go icon to follow link

CYP26B1 C Show summary »

CYP26C1 C Show summary »

Sterol 27-hydroxylase (CYP27A1) C Show summary »

25-Hydroxyvitamin D 1-alpha-hydroxylase (CYP27B1) C Show summary »

Target Id 1370
Nomenclature CYP27B1
Common abbreviation 25-Hydroxyvitamin D 1-alpha-hydroxylase
Previous and unofficial names calcidiol 1-monooxygenase | VD3 1A hydroxylase | cytochrome P450 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase) | cytochrome P450, family 27, subfamily B, polypeptide 1 | cytochrome P450
Genes CYP27B1 (Hs), Cyp27b1 (Mm), Cyp27b1 (Rn)
Ensembl ID ENSG00000111012 (Hs), ENSMUSG00000006724 (Mm), ENSRNOG00000046214 (Rn)
UniProtKB AC O15528 (Hs), O35084 (Mm), O35132 (Rn)
EC number
CTA091 pIC50 6.3 [3]
Comment Converts 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 (calcitriol)

CYP27C1 C Show summary »


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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.