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Prostaglandin synthases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Subsequent to the formation of PGH2, the cytochrome P450 activities thromboxane synthase (CYP5A1, TBXAS1, P24557 , EC and prostacyclin synthase (CYP8A1, PTGIS, Q16647, EC generate thromboxane A2 and prostacyclin (PGI2), respectively. Additionally, multiple enzyme activities are able to generate prostaglandin E2 (PGE2), prostaglandin D2 (PGD2) and prostaglandin F (PGF). PGD2 can be metabolised to 9α,11β-prostacyclin F through the multifunctional enzyme activity of AKR1C3. PGE2 can be metabolised to 9α,11β-prostaglandin F through the 9-ketoreductase activity of CBR1. Conversion of the 15-hydroxyecosanoids, including prostaglandins, lipoxins and leukotrienes to their keto derivatives by the NAD-dependent enzyme HPGD leads to a reduction in their biological activity.


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Thromboxane-A synthase (CYP5A1) C Show summary » More detailed page go icon to follow link

Prostacyclin synthase (CYP8A1) C Show summary »

mPGES1 C Show summary » More detailed page go icon to follow link

mPGES2 C Show summary »

Target Id 1378
Nomenclature mPGES2
Previous and unofficial names microsomal prostaglandin E synthase 2 | mPGES-2 | GBF1 | GBF-1
Genes PTGES2 (Hs), Ptges2 (Mm), Ptges2 (Rn)
Ensembl ID ENSG00000148334 (Hs), ENSMUSG00000026820 (Mm), ENSRNOG00000014050 (Rn)
UniProtKB AC Q9H7Z7 (Hs), Q8BWM0 (Mm)
EC number PGH2 = PGE2
dihydrolipoic acid [25]
compound 30 [PMID: 15953724] pIC50 <6.0 [22]

cPGES C Show summary »

L-PGDS C Show summary »

H-PGDS C Show summary »

AKR1C3 C Show summary » More detailed page go icon to follow link

CBR1 C Show summary »

HPGD C Show summary » More detailed page go icon to follow link


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.