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Prostaglandin synthases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Subsequent to the formation of PGH2, the cytochrome P450 activities thromboxane synthase (CYP5A1, TBXAS1, P24557 , EC and prostacyclin synthase (CYP8A1, PTGIS, Q16647, EC generate thromboxane A2 and prostacyclin (PGI2), respectively. Additionally, multiple enzyme activities are able to generate prostaglandin E2 (PGE2), prostaglandin D2 (PGD2) and prostaglandin F (PGF). PGD2 can be metabolised to 9α,11β-prostacyclin F through the multifunctional enzyme activity of AKR1C3. PGE2 can be metabolised to 9α,11β-prostaglandin F through the 9-ketoreductase activity of CBR1. Conversion of the 15-hydroxyecosanoids, including prostaglandins, lipoxins and leukotrienes to their keto derivatives by the NAD-dependent enzyme HPGD leads to a reduction in their biological activity.


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Thromboxane-A synthase (CYP5A1) C Show summary » More detailed page go icon to follow link

Prostacyclin synthase (CYP8A1) C Show summary »

mPGES1 C Show summary » More detailed page go icon to follow link

mPGES2 C Show summary »

cPGES C Show summary »

Target Id 1379
Nomenclature cPGES
Previous and unofficial names Cytosolic prostaglandin E2 synthase | prostaglandin E synthase 3 | telomerase-binding protein p23 | TEBP | prostaglandin E synthase 3 (cytosolic)
Genes PTGES3 (Hs), Ptges3 (Mm), Ptges3 (Rn)
Ensembl ID ENSG00000110958 (Hs), ENSMUSG00000071072 (Mm), ENSRNOG00000002642 (Rn)
UniProtKB AC Q15185 (Hs), Q9R0Q7 (Mm), P83868 (Rn)
EC number PGH2 = PGE2
Comment Phosphorylated and activated by casein kinase 2 (CK2) [14].
Appears to regulate steroid hormone function by interaction with dimeric hsp90 [2,13].

L-PGDS C Show summary »

H-PGDS C Show summary »

AKR1C3 C Show summary » More detailed page go icon to follow link

CBR1 C Show summary »

HPGD C Show summary » More detailed page go icon to follow link


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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.