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Prostaglandin synthases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Subsequent to the formation of PGH2, the cytochrome P450 activities thromboxane synthase (CYP5A1, TBXAS1, P24557 , EC and prostacyclin synthase (CYP8A1, PTGIS, Q16647, EC generate thromboxane A2 and prostacyclin (PGI2), respectively. Additionally, multiple enzyme activities are able to generate prostaglandin E2 (PGE2), prostaglandin D2 (PGD2) and prostaglandin F (PGF). PGD2 can be metabolised to 9α,11β-prostacyclin F through the multifunctional enzyme activity of AKR1C3. PGE2 can be metabolised to 9α,11β-prostaglandin F through the 9-ketoreductase activity of CBR1. Conversion of the 15-hydroxyecosanoids, including prostaglandins, lipoxins and leukotrienes to their keto derivatives by the NAD-dependent enzyme HPGD leads to a reduction in their biological activity.


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Thromboxane-A synthase (CYP5A1) C Show summary » More detailed page go icon to follow link

Prostacyclin synthase (CYP8A1) C Show summary »

mPGES1 C Show summary » More detailed page go icon to follow link

mPGES2 C Show summary »

cPGES C Show summary »

L-PGDS C Show summary »

H-PGDS C Show summary »

Target Id 1381
Nomenclature H-PGDS
Previous and unofficial names Hematopoietic prostaglandin D synthase | HPGDS | GSTS1-1 | PGDS | glutathione S-transferase sigma | glutathione S-transferase | glutathione-dependent PGD synthase | prostaglandin D2 synthase 2 hematopoietic | Ptgds2
Genes HPGDS (Hs), Hpgds (Mm), Hpgds (Rn)
Ensembl ID ENSG00000163106 (Hs), ENSMUSG00000029919 (Mm), ENSRNOG00000006583 (Rn)
UniProtKB AC O60760 (Hs), Q9JHF7 (Mm), O35543 (Rn)
EC number PGH2 = PGD2
TFC007 pIC50 7.1 [19]
HQL-79 pIC50 5.3 – 5.5 [1]

AKR1C3 C Show summary » More detailed page go icon to follow link

CBR1 C Show summary »

HPGD C Show summary » More detailed page go icon to follow link


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.