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Lipid phosphate phosphatases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Lipid phosphate phosphatases, divided into phosphatidic acid phosphatases or lipins catalyse the dephosphorylation of phosphatidic acid (and other phosphorylated lipid derivatives) to generate inorganic phosphate and diacylglycerol. PTEN, a phosphatase and tensin homolog (BZS, MHAM, MMAC1, PTEN1, TEP1) is a phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase which acts as a tumour suppressor by reducing cellular levels of PI 3,4,5-P, thereby toning down activity of PDK1 and PKB. Loss-of-function mutations are frequently identified as somatic mutations in cancers.

Enzymes

1435
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Lipin1 C Show summary »


Target Id 1435
Nomenclature Lipin1
Previous and unofficial names phosphatidate phosphatase LPIN1
Genes LPIN1 (Hs), Lpin1 (Mm), Lpin1 (Rn)
Ensembl ID ENSG00000134324 (Hs), ENSMUSG00000020593 (Mm), ENSRNOG00000004377 (Rn)
UniProtKB AC Q14693 (Hs), Q91ZP3 (Mm)
EC number
3.1.3.4

Lipin2 C Show summary »

Lipin3 C Show summary »

PPA2A C Show summary »

PPA2B C Show summary »

PPA3A C Show summary »

PTEN (phosphatase and tensin homolog) C Show summary » More detailed page go icon to follow link

Further reading

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How to cite this family page

Database page citation:

Lipid phosphate phosphatases. Accessed on 20/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=277.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.