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Lipid phosphate phosphatases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Lipid phosphate phosphatases, divided into phosphatidic acid phosphatases or lipins catalyse the dephosphorylation of phosphatidic acid (and other phosphorylated lipid derivatives) to generate inorganic phosphate and diacylglycerol. PTEN, a phosphatase and tensin homolog (BZS, MHAM, MMAC1, PTEN1, TEP1) is a phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase which acts as a tumour suppressor by reducing cellular levels of PI 3,4,5-P, thereby toning down activity of PDK1 and PKB. Loss-of-function mutations are frequently identified as somatic mutations in cancers.

Enzymes

1436
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Lipin1 C Show summary »

Lipin2 C Show summary »


Target Id 1436
Nomenclature Lipin2
Previous and unofficial names phosphatidate phosphatase LPIN2
Genes LPIN2 (Hs), Lpin2 (Mm), Lpin2 (Rn)
Ensembl ID ENSG00000101577 (Hs), ENSMUSG00000024052 (Mm), ENSRNOG00000014876 (Rn)
UniProtKB AC Q92539 (Hs), Q99PI5 (Mm)
EC number
3.1.3.4
Substrates
phosphatidic acid

Lipin3 C Show summary »

PPA2A C Show summary »

PPA2B C Show summary »

PPA3A C Show summary »

PTEN (phosphatase and tensin homolog) C Show summary » More detailed page go icon to follow link

Further reading

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How to cite this family page

Database page citation:

Lipid phosphate phosphatases. Accessed on 03/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=277.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.