Top ▲

Lipid phosphate phosphatases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

Lipid phosphate phosphatases, divided into phosphatidic acid phosphatases or lipins catalyse the dephosphorylation of phosphatidic acid (and other phosphorylated lipid derivatives) to generate inorganic phosphate and diacylglycerol. PTEN, a phosphatase and tensin homolog (BZS, MHAM, MMAC1, PTEN1, TEP1) is a phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase which acts as a tumour suppressor by reducing cellular levels of PI 3,4,5-P, thereby toning down activity of PDK1 and PKB. Loss-of-function mutations are frequently identified as somatic mutations in cancers.

Enzymes

1437
Click here for help

Lipin1 C Show summary »

Lipin2 C Show summary »

Lipin3 C Show summary »


Target Id 1437
Nomenclature Lipin3
Previous and unofficial names SMP2 | phosphatidate phosphatase LPIN3
Genes LPIN3 (Hs), Lpin3 (Mm), Lpin3 (Rn)
Ensembl ID ENSG00000132793 (Hs), ENSMUSG00000027412 (Mm), ENSRNOG00000016636 (Rn)
UniProtKB AC Q9BQK8 (Hs), Q99PI4 (Mm)
EC number
3.1.3.4

PPA2A C Show summary »

PPA2B C Show summary »

PPA3A C Show summary »

PTEN (phosphatase and tensin homolog) C Show summary » More detailed page go icon to follow link

Further reading

Click here for help

Show »

How to cite this family page

Database page citation:

Lipid phosphate phosphatases. Accessed on 09/12/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=277.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.