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Inositol polyphosphate phosphatases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Members of this family exhibit phosphatase activity towards IP3, as well as towards other inositol derivatives, including the phospholipids PIP2 and PIP3. With IP3 as substrate, 1-phosphatase (EC 3.1.3.57) generates 4,5,-IP2, 4-phosphatases (EC 3.1.3.66, ENSFM00250000001432) generate 1,5,-IP2 and 5-phosphatases (E.C. 3.1.3.36 or 3.1.3.56) generate 1,4,-IP2.

Enzymes

1452
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INPP1 Show summary »

INPP4A Show summary »

INPP4B Show summary »


Target Id 1452
Nomenclature INPP4B
Previous and unofficial names 105 kDa INPP4 | inositol polyphosphate-4-phosphatase type II 105kD | type II inositol 3,4-bisphosphate 4-phosphatase | inositol polyphosphate-4-phosphatase, type II, 105kDa | inositol polyphosphate-4-phosphatase
Genes INPP4B (Hs), Inpp4b (Mm), Inpp4b (Rn)
Ensembl ID ENSG00000109452 (Hs), ENSMUSG00000037940 (Mm), ENSRNOG00000018382 (Rn)
UniProtKB AC O15327 (Hs), Q6P1Y8 (Mm), Q9QWG5 (Rn)
EC number
3.1.3.36

INPP5A Show summary »

INPP5B Show summary »

SHIP1 (INPP5D) Show summary » More detailed page go icon to follow link

INPP5E Show summary »

INPP5J Show summary »

INPP5K Show summary »

INPPL1 Show summary »

OCRL Show summary »

SYNJ1 Show summary »

SYNJ2 Show summary »

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References

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How to cite this family page

Database page citation:

Inositol polyphosphate phosphatases. Accessed on 17/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=281.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.