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Inositol polyphosphate phosphatases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Members of this family exhibit phosphatase activity towards IP3, as well as towards other inositol derivatives, including the phospholipids PIP2 and PIP3. With IP3 as substrate, 1-phosphatase (EC 3.1.3.57) generates 4,5,-IP2, 4-phosphatases (EC 3.1.3.66, ENSFM00250000001432) generate 1,5,-IP2 and 5-phosphatases (E.C. 3.1.3.36 or 3.1.3.56) generate 1,4,-IP2.

Enzymes

1453
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INPP1 Show summary »

INPP4A Show summary »

INPP4B Show summary »

INPP5A Show summary »


Target Id 1453
Nomenclature INPP5A
Previous and unofficial names 5PTASE | 43 kDa inositol polyphosphate 5-phophatase | CTCL tumor antigen HD-CL-02 | inositol polyphosphate 5-phophatase, 40kDa | InsP3 5-phosphatase | type I inositol-1,4,5-trisphosphate 5-phosphatase | inositol polyphosphate-5-phosphatase A | inositol polyphosphate-5-phosphatase, 40kDa
Genes INPP5A (Hs), Inpp5a (Mm), Inpp5a (Rn)
Ensembl ID ENSG00000068383; (Hs), ENSMUSG00000025477 (Mm), ENSRNOG00000017635 (Rn)
UniProtKB AC Q14642 (Hs)
EC number
3.1.3.56
Inhibitors
compound 5 [Noble et al., 1992] pKi 5.9 [2]

INPP5B Show summary »

SHIP1 (INPP5D) Show summary » More detailed page go icon to follow link

INPP5E Show summary »

INPP5J Show summary »

INPP5K Show summary »

INPPL1 Show summary »

OCRL Show summary »

SYNJ1 Show summary »

SYNJ2 Show summary »

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References

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How to cite this family page

Database page citation:

Inositol polyphosphate phosphatases. Accessed on 20/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=281.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.