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Inositol polyphosphate phosphatases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Members of this family exhibit phosphatase activity towards IP3, as well as towards other inositol derivatives, including the phospholipids PIP2 and PIP3. With IP3 as substrate, 1-phosphatase (EC 3.1.3.57) generates 4,5,-IP2, 4-phosphatases (EC 3.1.3.66, ENSFM00250000001432) generate 1,5,-IP2 and 5-phosphatases (E.C. 3.1.3.36 or 3.1.3.56) generate 1,4,-IP2.

Enzymes

1459
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INPP1 Show summary »

INPP4A Show summary »

INPP4B Show summary »

INPP5A Show summary »

INPP5B Show summary »

SHIP1 (INPP5D) Show summary » More detailed page go icon to follow link

INPP5E Show summary »

INPP5J Show summary »

INPP5K Show summary »

INPPL1 Show summary »


Target Id 1459
Nomenclature INPPL1
Previous and unofficial names SHIP2 | 51C protein | inositol polyphosphate phosphatase-like 1 | INPPL-1 | SH2 domain-containing inositol-5'-phosphatase 2 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
Genes INPPL1 (Hs), Inppl1 (Mm), Inppl1 (Rn)
Ensembl ID ENSG00000165458 (Hs), ENSMUSG00000032737 (Mm), ENSRNOG00000019730 (Rn)
UniProtKB AC O15357 (Hs), Q6P549 (Mm), Q9WVR3 (Rn)
EC number
3.1.3.86
Inhibitors
AS1949490 pIC50 6.2 [5]

OCRL Show summary »

SYNJ1 Show summary »

SYNJ2 Show summary »

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How to cite this family page

Database page citation:

Inositol polyphosphate phosphatases. Accessed on 17/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=281.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.