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SLC50 sugar transporter C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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A mouse stromal cell cDNA library was used to clone C2.3 [2], later termed Rag1-activating protein 1, with a sequence homology predictive of a 4TM topology. The plant orthologues, termed SWEETs, appear to be 7 TM proteins, with extracellular N-termini, and the capacity for bidirectional flux of D-glucose [1]. Expression of mouse SWEET in the mammary gland was suggestive of a role in Golgi lactose synthesis [1].

Transporters

1914
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RAG1AP1 (SLC50 sugar exporter / SLC50A1) C Show summary »


Target Id 1914
Nomenclature SLC50 sugar exporter
Systematic nomenclature SLC50A1
Common abbreviation RAG1AP1
Previous and unofficial names HsSWEET1 | RAG1AP1 | recombination activating gene 1 activating protein 1 | solute carrier family 50 (sugar transporter), member 1 | SWEET1 | solute carrier family 50 (sugar efflux transporter), member 1 | solute carrier family 50 (sugar transporter)
Genes SLC50A1 (Hs), Slc50a1 (Mm), Slc50a1 (Rn)
Ensembl ID ENSG00000169241 (Hs), ENSMUSG00000027953 (Mm), ENSRNOG00000020554 (Rn)
UniProtKB AC Q9BRV3 (Hs), Q9CXK4 (Mm), D3ZH22 (Rn)
Bioparadigms SLC Tables SLC50A1 (Hs)
RESOLUTE SLC50A1 (Hs)

Further reading

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References

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How to cite this family page

Database page citation:

SLC50 sugar transporter. Accessed on 04/02/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=336.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.