GEK subfamily

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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

DMPK1 (DM1 protein kinase) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1505

Nomenclature

DM1 protein kinase

Common abbreviation

DMPK1

Previous and unofficial names

Genes

DMPK (Hs), Dmpk (Mm), Dmpk (Rn)

Ensembl ID

ENSG00000104936 (Hs), ENSMUSG00000030409 (Mm), ENSRNOG00000015085 (Rn)

UniProtKB AC

Q09013 (Hs), P54265 (Mm)

EC number

2.7.11.1

Comment

Reduced expression of DMPK is associated with myotonic dystrophy 1 [3]

DMPK2 (CDC42 binding protein kinase gamma) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1506

Nomenclature

CDC42 binding protein kinase gamma

Common abbreviation

DMPK2

Previous and unofficial names

Genes

CDC42BPG (Hs), Cdc42bpg (Mm), Cdc42bpg (Rn)

Ensembl ID

ENSG00000171219 (Hs), ENSMUSG00000024769 (Mm), ENSRNOG00000027456 (Rn)

UniProtKB AC

Q6DT37 (Hs), Q80UW5 (Mm)

EC number

2.7.11.1

MRCKα (CDC42 binding protein kinase alpha) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1507

Nomenclature

CDC42 binding protein kinase alpha

Common abbreviation

MRCKα

Previous and unofficial names

Genes

CDC42BPA (Hs), Cdc42bpa (Mm), Cdc42bpa (Rn)

Ensembl ID

ENSG00000143776 (Hs), ENSMUSG00000026490 (Mm), ENSRNOG00000002841 (Rn)

UniProtKB AC

Q5VT25 (Hs), Q3UU96 (Mm), O54874 (Rn)

EC number

2.7.11.1

Comment

Reported to have a role in cellular iron regulation [1]

MRCKβ (CDC42 binding protein kinase beta) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1508

Nomenclature

CDC42 binding protein kinase beta

Common abbreviation

MRCKβ

Previous and unofficial names

Cdc42 binding protein kinase beta | MRCK beta | serine/threonine-protein kinase MRCK beta | CDC42 binding protein kinase beta (DMPK-like)

Genes

CDC42BPB (Hs), Cdc42bpb (Mm), Cdc42bpb (Rn)

Ensembl ID

ENSG00000198752 (Hs), ENSMUSG00000021279 (Mm), ENSRNOG00000009675 (Rn)

UniProtKB AC

Q9Y5S2 (Hs), Q7TT50 (Mm), Q7TT49 (Rn)

EC number

2.7.11.1

Comment

Reported to be involved in cell migration [2]

References

Show »« Hide

1. Cmejla R, Ptackova P, Petrak J, Savvulidi F, Cerny J, Sebesta O, Vyoral D. (2010) Human MRCKalpha is regulated by cellular iron levels and interferes with transferrin iron uptake. Biochem Biophys Res Commun, 395 (2): 163-7. [PMID:20188707]

2. Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M. (2011) Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration. EMBO J, 30 (4): 665-78. [PMID:21240187]

3. Kaliman P, Llagostera E. (2008) Myotonic dystrophy protein kinase (DMPK) and its role in the pathogenesis of myotonic dystrophy 1. Cell Signal, 20 (11): 1935-41. [PMID:18583094]

How to cite this family page

Database page citation:

GEK subfamily. Accessed on 16/08/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=500.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.