CDC42 binding protein kinase gamma | GEK subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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CDC42 binding protein kinase gamma

Target not currently curated in GtoImmuPdb

Target id: 1506

Nomenclature: CDC42 binding protein kinase gamma

Abbreviated Name: DMPK2

Family: GEK subfamily

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1551 11q13 CDC42BPG CDC42 binding protein kinase gamma
Mouse - 1551 19 Cdc42bpg CDC42 binding protein kinase gamma (DMPK-like)
Rat - 1551 1q43 Cdc42bpg CDC42 binding protein kinase gamma
Previous and Unofficial Names
HSMDPKIN | kappa-200 | MRCKγ | MRCKgamma | CDC42 binding protein kinase gamma (DMPK-like) | serine/threonine-protein kinase MRCK gamma | CDC42-binding protein kinase gamma | DMPK-like gamma | myotonic dystrophy protein kinase-like alpha | myotonic dystrophy protein kinase-like gamma | Myotonic dystrophy kinase-related CDC42 binding protein kinase γ | myotonic dystrophy kinase-related CDC42-binding kinase gamma
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: DMPK2
Ligand Sp. Type Action Value Parameter
staurosporine Hs Inhibitor Inhibition 7.4 pKd
foretinib Hs Inhibitor Inhibition 6.7 pKd
PD-173955 Hs Inhibitor Inhibition 6.6 pKd
SB203580 Hs Inhibitor Inhibition 6.4 pKd
A-674563 Hs Inhibitor Inhibition 6.3 pKd
dasatinib Hs Inhibitor Inhibition 5.9 pKd
doramapimod Hs Inhibitor Inhibition 5.9 pKd
KW-2449 Hs Inhibitor Inhibition 5.7 pKd
vandetanib Hs Inhibitor Inhibition 5.7 pKd
lestaurtinib Hs Inhibitor Inhibition 5.6 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

GEK subfamily: CDC42 binding protein kinase gamma. Last modified on 29/01/2016. Accessed on 29/01/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1506.