KHS subfamily
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
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MAP kinase kinase kinase kinases (MAP4Ks) belong to the mammalian STE20-like family of serine/threonine kinases. Four members of the family (MAP4K1/HPK1, MAP4kK2/GCK, MAP4K3/GLK or KHS2 and MAP4K5/KHS1) are included in this KHS subfamily, whilst the fifth member (MAP4K4/HGK) resides in the MSN subfamily. The functions of the MAP4Ks in immunity and inflammation are reviewed by Chuang et al. (2016) [1].
Enzymes
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HPK1 (mitogen-activated protein kinase kinase kinase kinase 1)
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GCK (mitogen-activated protein kinase kinase kinase kinase 2)
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KHS2 (mitogen-activated protein kinase kinase kinase kinase 3)
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KHS1 (mitogen-activated protein kinase kinase kinase kinase 5)
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How to cite this family page
Database page citation:
KHS subfamily. Accessed on 19/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=543.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.
