KHS subfamily

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Kinases (EC 2.7.x.x)
STE: Homologs of yeast Sterile 7, Sterile 11, Sterile 20 kinases
STE20 family
KHS subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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MAP kinase kinase kinase kinases (MAP4Ks) belong to the mammalian STE20-like family of serine/threonine kinases. Four members of the family (MAP4K1/HPK1, MAP4kK2/GCK, MAP4K3/GLK or KHS2 and MAP4K5/KHS1) are included in this KHS subfamily, whilst the fifth member (MAP4K4/HGK) resides in the MSN subfamily. The functions of the MAP4Ks in immunity and inflammation are reviewed by Chuang et al. (2016) [1].

Enzymes

HPK1 (mitogen-activated protein kinase kinase kinase kinase 1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2085

Nomenclature

mitogen-activated protein kinase kinase kinase kinase 1

Common abbreviation

HPK1

Previous and unofficial names

hematopoietic progenitor kinase 1 | MAPK/ERK kinase kinase kinase 1

Genes

MAP4K1 (Hs), Map4k1 (Mm), Map4k1 (Rn)

Ensembl ID

ENSG00000104814 (Hs), ENSMUSG00000037337 (Mm), ENSRNOG00000020505 (Rn)

UniProtKB AC

Q92918 (Hs), P70218 (Mm)

EC number

2.7.11.1

GCK (mitogen-activated protein kinase kinase kinase kinase 2) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2086

Nomenclature

mitogen-activated protein kinase kinase kinase kinase 2

Common abbreviation

GCK

Previous and unofficial names

Genes

MAP4K2 (Hs), Map4k2 (Mm), Map4k2 (Rn)

Ensembl ID

ENSG00000168067 (Hs), ENSMUSG00000024948 (Mm), ENSRNOG00000021061 (Rn)

UniProtKB AC

Q12851 (Hs), Q61161 (Mm)

EC number

2.7.11.1

KHS2 (mitogen-activated protein kinase kinase kinase kinase 3) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2087

Nomenclature

mitogen-activated protein kinase kinase kinase kinase 3

Common abbreviation

KHS2

Previous and unofficial names

GLK | MAPK/ERK kinase kinase kinase 3 | MAPKKKK3 | MEKKK 3 | RAB8IPL1

Genes

MAP4K3 (Hs), Map4k3 (Mm), Map4k3 (Rn)

Ensembl ID

ENSG00000011566 (Hs), ENSMUSG00000024242 (Mm), ENSRNOG00000007172 (Rn)

UniProtKB AC

Q8IVH8 (Hs), Q99JP0 (Mm), Q924I2 (Rn)

EC number

2.7.11.1

KHS1 (mitogen-activated protein kinase kinase kinase kinase 5) Show summary »« Hide summary More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

KHS subfamily. Accessed on 28/11/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=543.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.