KHS subfamily: Introduction
MAP kinase kinase kinase kinases (MAP4Ks) belong to the mammalian STE20-like family of serine/threonine kinases. Five MAP4K genes have been identified in the human genome. These are listed in the table below
The functions of the MAP4Ks in immunity and inflammation are reviewed by Chuang et al. (2016) [1].
| Gene symbol | Commonly used nomenclature | Kinase subfamily |
|---|---|---|
| MAP4K1 | hematopoietic progenitor kinase 1, HPK1 | KHS subfamily |
| MAP4K2 | germinal center kinase, GCK | KHS subfamily |
| MAP4K3 | germinal-center kinase-like kinase, GLK, KHS2 | KHS subfamily |
| MAP4K4 | hepatocyte progenitor kinase-like kinase, HGK | MSN subfamily |
| MAP4K5 | GCK-related protein kinase, KHS1 | KHS subfamily |
The functions of the MAP4Ks in immunity and inflammation are reviewed by Chuang et al. (2016) [1].
How to cite this page
To cite this family introduction, please use the following:
KHS subfamily, introduction. Last modified on 31/05/2018. Accessed on 30/04/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=543.
