Top ▲

Abl family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

« Hide

ABL1 is a tyrosine kinase. Deletion of the kinase's inhibitory SH3 domain converts it into an oncogene. A fusion protein caused by a gene translocation, t(9;22), that generates a BCR-ABL fusion is present in many cases of chronic myelogenous leukemia (CML). The clinically approved drug imatinib, was the first kinase inhibitor to target ABL1 activity to treat CML.


Click here for help

Abl (ABL proto-oncogene 1, non-receptor tyrosine kinase) C Show summary » More detailed page go icon to follow link

Arg (ABL proto-oncogene 2, non-receptor tyrosine kinase) Show summary » More detailed page go icon to follow link


Click here for help

Show »

How to cite this family page

Database page citation:

Abl family. Accessed on 17/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.