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Abl family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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ABL1 is a tyrosine kinase. Deletion of the kinase's inhibitory SH3 domain converts it into an oncogene. A fusion protein caused by a gene translocation, t(9;22), that generates a BCR-ABL fusion is present in many cases of chronic myelogenous leukemia (CML). The clinically approved drug imatinib, was the first kinase inhibitor to target ABL1 activity to treat CML.

Enzymes

Abl (ABL proto-oncogene 1, non-receptor tyrosine kinase) C Show summary » More detailed page

Arg (ABL proto-oncogene 2, non-receptor tyrosine kinase) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Abl family. Accessed on 22/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=553.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.