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Abl family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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ABL1 is a tyrosine kinase. Deletion of the kinase's inhibitory SH3 domain converts it into an oncogene. A fusion protein caused by a gene translocation, t(9;22), that generates a BCR-ABL fusion is present in many cases of chronic myelogenous leukemia (CML). The clinically approved drug imatinib, was the first kinase inhibitor to target ABL1 activity to treat CML.

Enzymes

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Abl (ABL proto-oncogene 1, non-receptor tyrosine kinase) C Show summary » More detailed page go icon to follow link

Arg (ABL proto-oncogene 2, non-receptor tyrosine kinase) Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Abl family. Accessed on 17/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=553.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.