Top ▲
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
« Hide
More detailed introduction
Prokineticin receptors, PKR1 and PKR2 (provisional nomenclature as recommended by NC-IUPHAR [3]) respond to the cysteine-rich 81-86 amino-acid peptides prokineticin-1 (PROK1, Q9HC23) (also known as endocrine gland-derived vascular endothelial growth factor, mambakine) and prokineticin-2 (PROK2, Q9HC23) (protein Bv8 homologue). An orthologue of PROK1 from black mamba (Dendroaspis polylepis) venom, mamba intestinal toxin 1 (MIT1, [14]) is a potent, non-selective agonist at prokineticin receptors [9], while Bv8, an orthologue of PROK2 from amphibians (Bombina sp., [10]), is equipotent at recombinant PKR1 and PKR2 [11], and has high potency in macrophage chemotaxis assays, which are lost in PKR1-null mice.
PKR1
C
Show summary »
More detailed page |
PKR2
C
Show summary »
More detailed page |
Database page citation (select format):
Concise Guide to PHARMACOLOGY citation:
Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol. 176 Suppl 1:S27-S156.
Genetic mutations in PROKR1 are associated with Hirschsprung's disease [13], while genetic mutations in PROKR2 are associated with hypogonadotropic hypogonadism with anosmia [2], hypopituitarism with pituitary stalk interruption [12] and Hirschsprung's disease [13]. PKR2 has been recently identified as a receptor for T. cruzi natural infection [5]. PROK2 neuropeptide signalling via PKR2 on spinal neurons generates pleasant touch sensation [8].