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Prokineticin receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Prokineticin receptors, PKR1 and PKR2 (provisional nomenclature as recommended by NC-IUPHAR [3]) respond to the cysteine-rich 81-86 amino-acid peptides prokineticin-1 (PROK1, Q9HC23) (also known as endocrine gland-derived vascular endothelial growth factor, mambakine) and prokineticin-2 (PROK2, Q9HC23) (protein Bv8 homologue). An orthologue of PROK1 from black mamba (Dendroaspis polylepis) venom, mamba intestinal toxin 1 (MIT1, [13]) is a potent, non-selective agonist at prokineticin receptors [8], while Bv8, an orthologue of PROK2 from amphibians (Bombina sp., [9]), is equipotent at recombinant PKR1 and PKR2 [10], and has high potency in macrophage chemotaxis assays, which are lost in PKR1-null mice.

Receptors

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PKR1 C Show summary » More detailed page go icon to follow link

PKR2 C Show summary » More detailed page go icon to follow link

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol. 176 Suppl 1:S27-S156.