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Prostanoid receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Prostanoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Prostanoid Receptors [78]) are activated by the endogenous ligands prostaglandins PGD2, PGE1, PGE2 , PGF, PGH2, prostacyclin [PGI2] and thromboxane A2. Differences and similarities between human and rodent prostanoid receptor orthologues, and their specific roles in pathophysiologic conditions are reviewed in [45]. Measurement of the potency of PGI2 and thromboxane A2 is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies.

Receptors

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DP1 receptor C Show summary » More detailed page go icon to follow link

DP2 receptor C Show summary » More detailed page go icon to follow link

EP1 receptor C Show summary » More detailed page go icon to follow link

EP2 receptor C Show summary » More detailed page go icon to follow link

EP3 receptor C Show summary » More detailed page go icon to follow link

EP4 receptor C Show summary » More detailed page go icon to follow link

FP receptor C Show summary » More detailed page go icon to follow link

IP receptor C Show summary » More detailed page go icon to follow link

TP receptor C Show summary » More detailed page go icon to follow link

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol. 176 Suppl 1:S27-S156.