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RAF family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The RAF (acronym for rapidly accelerated fibrosarcoma) kinases are a family of related Ser/Thr kinases that are important for normal cellular and physiological processes, but are also associated with oncogenesis [6]. They are components of the Ras-Raf-MAPK signalling pathway.

Enzymes

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A-Raf (A-Raf proto-oncogene, serine/threonine kinase) Show summary » More detailed page go icon to follow link

B-Raf (B-Raf proto-oncogene, serine/threonine kinase) C Show summary » More detailed page go icon to follow link

KSR (kinase suppressor of ras 1) Show summary » More detailed page go icon to follow link

KSR2 (kinase suppressor of ras 2) Show summary » More detailed page go icon to follow link

c-Raf (Raf-1 proto-oncogene, serine/threonine kinase) C Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

RAF family. Accessed on 02/03/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=610.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.