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kinase suppressor of ras 2

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Target not currently curated in GtoImmuPdb

Target id: 2052

Nomenclature: kinase suppressor of ras 2

Abbreviated Name: KSR2

Family: RAF family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 950 12q24.22-q24.23 KSR2 kinase suppressor of ras 2
Mouse - 960 5 F Ksr2 kinase suppressor of ras 2
Rat - - 12q16 Ksr2 kinase suppressor of ras 2
Database Links Click here for help
Alphafold Q6VAB6 (Hs), Q3UVC0 (Mm), F1LY04 (Rn)
ChEMBL Target CHEMBL3627583 (Hs)
Ensembl Gene ENSG00000171435 (Hs), ENSMUSG00000061578 (Mm), ENSRNOG00000028630 (Rn)
Entrez Gene 283455 (Hs), 333050 (Mm), 288691 (Rn)
Human Protein Atlas ENSG00000171435 (Hs)
KEGG Gene hsa:283455 (Hs), mmu:333050 (Mm), rno:288691 (Rn)
OMIM 610737 (Hs)
Pharos Q6VAB6 (Hs)
RefSeq Nucleotide NM_173598 (Hs), NM_001114545 (Mm)
RefSeq Protein NP_775869 (Hs), NP_001108017 (Mm)
UniProtKB Q6VAB6 (Hs), Q3UVC0 (Mm), F1LY04 (Rn)
Wikipedia KSR2 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  KSR2-MEK1 HETERODIMER
PDB Id:  2Y4I
Resolution:  3.46Å
Species:  Human
References:  1

References

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1. Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D. (2011) A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature, 472 (7343): 366-9. [PMID:21441910]

How to cite this page

RAF family: kinase suppressor of ras 2. Last modified on 18/08/2014. Accessed on 23/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2052.