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Fatty acid-binding proteins C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Fatty acid-binding proteins are low molecular weight (100-130 aa) chaperones for long chain fatty acids, fatty acyl CoA esters, eicosanoids, retinols, retinoic acids and related metabolites and are usually regarded as being responsible for allowing the otherwise hydrophobic ligands to be mobile in aqueous media. These binding proteins may perform functions extracellularly (e.g. in plasma) or transport these agents; to the nucleus to interact with nuclear receptors (principally PPARs and retinoic acid receptors [13]) or for interaction with metabolic enzymes. Although sequence homology is limited, crystallographic studies suggest conserved 3D structures across the group of binding proteins.

Targets

2530
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fatty acid binding protein 1 C Show summary »

fatty acid binding protein 2 C Show summary »

fatty acid binding protein 3 C Show summary » More detailed page go icon to follow link

fatty acid binding protein 4 C Show summary » More detailed page go icon to follow link

fatty acid binding protein 5 C Show summary »

fatty acid binding protein 6 C Show summary »

fatty acid binding protein 7 C Show summary »

peripheral myelin protein 2 C Show summary »

fatty acid binding protein 9 C Show summary »

fatty acid binding protein 12 C Show summary »

retinol binding protein 1 C Show summary »

retinol binding protein 2 C Show summary »

retinol binding protein 3 C Show summary »

retinol binding protein 4 C Show summary » More detailed page go icon to follow link

retinol binding protein 5 C Show summary »

retinol binding protein 7 C Show summary »

retinaldehyde binding protein 1 C Show summary »

cellular retinoic acid binding protein 1 C Show summary »

cellular retinoic acid binding protein 2 C Show summary »


Target Id 2530
Nomenclature cellular retinoic acid binding protein 2
Previous and unofficial names cellular lipid-binding protein
Genes CRABP2 (Hs), Crabp2 (Mm), Crabp2 (Rn)
Ensembl ID ENSG00000143320 (Hs), ENSMUSG00000004885 (Mm), ENSRNOG00000022101 (Rn)
UniProtKB AC P29373 (Hs), P22935 (Mm), P51673 (Rn)

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How to cite this family page

Database page citation:

Fatty acid-binding proteins. Accessed on 10/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=783.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.