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Fatty acid-binding proteins C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Fatty acid-binding proteins are low molecular weight (100-130 aa) chaperones for long chain fatty acids, fatty acyl CoA esters, eicosanoids, retinols, retinoic acids and related metabolites and are usually regarded as being responsible for allowing the otherwise hydrophobic ligands to be mobile in aqueous media. These binding proteins may perform functions extracellularly (e.g. in plasma) or transport these agents; to the nucleus to interact with nuclear receptors (principally PPARs and retinoic acid receptors [13]) or for interaction with metabolic enzymes. Although sequence homology is limited, crystallographic studies suggest conserved 3D structures across the group of binding proteins.

Targets

2547
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fatty acid binding protein 1 C Show summary »

fatty acid binding protein 2 C Show summary »

fatty acid binding protein 3 C Show summary » More detailed page go icon to follow link

fatty acid binding protein 4 C Show summary » More detailed page go icon to follow link

fatty acid binding protein 5 C Show summary »

fatty acid binding protein 6 C Show summary »

fatty acid binding protein 7 C Show summary »

peripheral myelin protein 2 C Show summary »

fatty acid binding protein 9 C Show summary »

fatty acid binding protein 12 C Show summary »

retinol binding protein 1 C Show summary »

retinol binding protein 2 C Show summary »


Target Id 2547
Nomenclature retinol binding protein 2
Previous and unofficial names CRABP-II | CRBP2 | retinol binding protein 2, cellular
Genes RBP2 (Hs), Rbp2 (Mm), Rbp2 (Rn)
Ensembl ID ENSG00000114113 (Hs), ENSMUSG00000032454 (Mm), ENSRNOG00000013932 (Rn)
UniProtKB AC P50120 (Hs), Q08652 (Mm), P06768 (Rn)
Rank order of potency stearic acid > palmitic acid, oleic acid, linoleic acid, α-linolenic acid, arachidonic acid  [11]

retinol binding protein 3 C Show summary »

retinol binding protein 4 C Show summary » More detailed page go icon to follow link

retinol binding protein 5 C Show summary »

retinol binding protein 7 C Show summary »

retinaldehyde binding protein 1 C Show summary »

cellular retinoic acid binding protein 1 C Show summary »

cellular retinoic acid binding protein 2 C Show summary »

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References

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How to cite this family page

Database page citation:

Fatty acid-binding proteins. Accessed on 28/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=783.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.