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Serine palmitoyltransferase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The functional enzyme is a heterodimer of SPT1 (LCB1) with either SPT2 (LCB2) or SPT3 (LCB2B); the small subunits of SPT (ssSPTa or ssSPTb) bind to the heterodimer to enhance enzymatic activity. The complexes of SPT1/SPT2/ssSPTa and SPT1/SPT2/ssSPTb were most active with palmitoylCoA as substrate, with the latter complex also showing some activity with stearoylCoA [1]. Complexes involving SPT3 appeared more broad in substrate selectivity, with incorporation of myristoylCoA prominent for SPT1/SPT3/ssSPTa complexes, while SP1/SPT3/ssSPTb complexes had similar activity with C16, C18 and C20 acylCoAs [1].

Enzymes

2511
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SPT1 (serine palmitoyltransferase long chain base subunit 1) C Show summary » More detailed page go icon to follow link

SPT2 (serine palmitoyltransferase long chain base subunit 2) C Show summary »

SPT3 (serine palmitoyltransferase long chain base subunit 3) C Show summary »


Target Id 2511
Nomenclature serine palmitoyltransferase long chain base subunit 3
Common abbreviation SPT3
Previous and unofficial names LCB 3 | LCB2b | Long chain base biosynthesis protein 2b | Serine-palmitoyl-CoA transferase 3 | SPT 3 | SPTLC2L | serine palmitoyltransferase, long chain base subunit 3 | serine palmitoyltransferase
Genes SPTLC3 (Hs), Sptlc3 (Mm), Sptlc3 (Rn)
Ensembl ID ENSG00000172296 (Hs), ENSMUSG00000039092 (Mm), ENSRNOG00000004443 (Rn)
UniProtKB AC Q9NUV7 (Hs), Q8BG54 (Mm), D4A9V0 (Rn)
EC number
2.3.1.50 L-serine + palmitoyl-CoA -> 3-ketosphinganine + coenzyme A + CO2
Cofactors
pyridoxal 5-phosphate
Selective inhibitors
myriocin [3]

SPTSSA (serine palmitoyltransferase small subunit A) C Show summary »

SPTSSB (serine palmitoyltransferase small subunit B) C Show summary »

References

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.