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Serine palmitoyltransferase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The functional enzyme is a heterodimer of SPT1 (LCB1) with either SPT2 (LCB2) or SPT3 (LCB2B); the small subunits of SPT (ssSPTa or ssSPTb) bind to the heterodimer to enhance enzymatic activity. The complexes of SPT1/SPT2/ssSPTa and SPT1/SPT2/ssSPTb were most active with palmitoylCoA as substrate, with the latter complex also showing some activity with stearoylCoA [1]. Complexes involving SPT3 appeared more broad in substrate selectivity, with incorporation of myristoylCoA prominent for SPT1/SPT3/ssSPTa complexes, while SP1/SPT3/ssSPTb complexes had similar activity with C16, C18 and C20 acylCoAs [1].

Enzymes

2512
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SPT1 (serine palmitoyltransferase long chain base subunit 1) C Show summary » More detailed page go icon to follow link

SPT2 (serine palmitoyltransferase long chain base subunit 2) C Show summary »

SPT3 (serine palmitoyltransferase long chain base subunit 3) C Show summary »

SPTSSA (serine palmitoyltransferase small subunit A) C Show summary »


Target Id 2512
Nomenclature serine palmitoyltransferase small subunit A
Common abbreviation SPTSSA
Previous and unofficial names ssSPTa | serine palmitoyltransferase, small subunit A | serine palmitoyltransferase
Genes SPTSSA (Hs), Sptssa (Mm), Sptssa (Rn)
Ensembl ID ENSG00000165389 (Hs), ENSMUSG00000044408 (Mm), ENSRNOG00000004292 (Rn)
UniProtKB AC Q969W0 (Hs), Q8R207 (Mm), Q4G019 (Rn)

SPTSSB (serine palmitoyltransferase small subunit B) C Show summary »

References

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.