Sphingolipid Δ<sup>4</sup>-desaturase | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

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Sphingolipid Δ⁴-desaturase

Sphingolipid Δ⁴-desaturase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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DEGS1 and DEGS2 are 4TM proteins.

Enzymes

delta 4-desaturase, sphingolipid 1 C Show summary »« Hide summary

Target Id

2484

Nomenclature

delta 4-desaturase, sphingolipid 1

Previous and unofficial names

Genes

DEGS1 (Hs), Degs1 (Mm), Degs1 (Rn)

Ensembl ID

ENSG00000143753 (Hs), ENSMUSG00000038633 (Mm), ENSRNOG00000003223 (Rn)

UniProtKB AC

O15121 (Hs), O09005 (Mm), Q5XIF5 (Rn)

EC number

1.14.-.-

Cofactors

NAD

Inhibitors

SKI II pK_i 6.5 [3]

RBM2-1B pIC₅₀ 4.7 [2]

Comment

Myristoylation of DEGS1 enhances its activity and targets it to the mitochondria [1].

delta 4-desaturase, sphingolipid 2 C Show summary »« Hide summary

Target Id

2485

Nomenclature

delta 4-desaturase, sphingolipid 2

Previous and unofficial names

DES2 | FADS8 | degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase | delta(4)-desaturase, sphingolipid 2 | delta(4)-desaturase

Genes

DEGS2 (Hs), Degs2 (Mm), Degs2 (Rn)

Ensembl ID

ENSG00000168350 (Hs), ENSMUSG00000021263 (Mm), ENSRNOG00000011716 (Rn)

UniProtKB AC

Q6QHC5 (Hs), Q8R2F2 (Mm), Q564G3 (Rn)

EC number

1.14.-.-

Cofactors

NAD

Comments

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References

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1. Beauchamp E, Tekpli X, Marteil G, Lagadic-Gossmann D, Legrand P, Rioux V. (2009) N-Myristoylation targets dihydroceramide Delta4-desaturase 1 to mitochondria: partial involvement in the apoptotic effect of myristic acid. Biochimie, 91 (11-12): 1411-9. [PMID:19647031]

2. Camacho L, Simbari F, Garrido M, Abad JL, Casas J, Delgado A, Fabriàs G. (2012) 3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate. Bioorg Med Chem, 20 (10): 3173-9. [PMID:22537678]

3. Cingolani F, Casasampere M, Sanllehí P, Casas J, Bujons J, Fabrias G. (2014) Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II. J Lipid Res, 55 (8): 1711-20. [PMID:24875537]

4. Fabrias G, Muñoz-Olaya J, Cingolani F, Signorelli P, Casas J, Gagliostro V, Ghidoni R. (2012) Dihydroceramide desaturase and dihydrosphingolipids: debutant players in the sphingolipid arena. Prog Lipid Res, 51 (2): 82-94. [PMID:22200621]

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.