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Patched family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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NPC1L1 acts in the gut epithelium to allow the accumulation of dietary cholesterol through a clathrin-dependent mechanism. Ezetimibe is used to reduce cholesterol absorption through inhibition of NPC1L1.

Further reading

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How to cite this family page

Database page citation:

Patched family. Accessed on 04/12/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=856.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.