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Poly ADP-ribose polymerases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The Poly ADP-ribose polymerase family is a series of enzymes, where the best characterised members are nuclear proteins which are thought to function by binding to single strand breaks in DNA, allowing the recruitment of repair enzymes by the synthesis of NAD-derived ADP-ribose polymers, which are subsequently degraded by a glycohydrolase (PARG, Q86W56). The most well defined function of the tankyrases (TNKSs) is their regulatory action on Wnt/β-catenin signalling [3]. PARPs 1 and 2 are targets of PARP inhibitor class anti-cancer drugs which are designed to disrupt the DNA damage response pathways to induce cancer cell death.

Enzymes

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PARP1 (poly(ADP-ribose) polymerase 1) C Show summary » More detailed page go icon to follow link

PARP2 (poly(ADP-ribose) polymerase 2) C Show summary » More detailed page go icon to follow link

PARP3 (poly (ADP-ribose) polymerase 3) C Show summary » More detailed page go icon to follow link

tankyrase Show summary » More detailed page go icon to follow link

tankyrase 2 Show summary » More detailed page go icon to follow link

Further reading

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References

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How to cite this family page

Database page citation:

Poly ADP-ribose polymerases. Accessed on 09/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=883.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.