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Poly ADP-ribose polymerases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The Poly ADP-ribose polymerase family is a series of enzymes, where the best characterised members are nuclear proteins which are thought to function by binding to single strand breaks in DNA, allowing the recruitment of repair enzymes by the synthesis of NAD-derived ADP-ribose polymers, which are subsequently degraded by a glycohydrolase (PARG, Q86W56). The most well defined function of the tankyrases (TNKSs) is their regulatory action on Wnt/β-catenin signalling [2].

Enzymes

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PARP1 (poly(ADP-ribose) polymerase 1) C Show summary » More detailed page go icon to follow link

PARP2 (poly(ADP-ribose) polymerase 2) C Show summary » More detailed page go icon to follow link

PARP3 (poly (ADP-ribose) polymerase 3) C Show summary » More detailed page go icon to follow link

tankyrase Show summary » More detailed page go icon to follow link

tankyrase 2 Show summary » More detailed page go icon to follow link

Further reading

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References

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How to cite this family page

Database page citation:

Poly ADP-ribose polymerases. Accessed on 23/07/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=883.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.