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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
The Poly ADP-ribose polymerase family is a series of enzymes, where the best characterised members are nuclear proteins which are thought to function by binding to single strand breaks in DNA, allowing the recruitment of repair enzymes by the synthesis of NAD-derived ADP-ribose polymers, which are subsequently degraded by a glycohydrolase (PARG, Q86W56). The most well defined function of the tankyrases (TNKSs) is their regulatory action on Wnt/β-catenin signalling [2].
PARP1 (poly(ADP-ribose) polymerase 1)
C
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PARP2 (poly(ADP-ribose) polymerase 2)
C
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PARP3 (poly (ADP-ribose) polymerase 3)
C
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tankyrase
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tankyrase 2
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Database page citation:
Poly ADP-ribose polymerases. Accessed on 22/03/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=883.
Concise Guide to PHARMACOLOGY citation:
Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.