poly(ADP-ribose) polymerase 2 | Poly ADP-ribose polymerases | IUPHAR/BPS Guide to PHARMACOLOGY

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poly(ADP-ribose) polymerase 2

Target not currently curated in GtoImmuPdb

Target id: 2772

Nomenclature: poly(ADP-ribose) polymerase 2

Abbreviated Name: PARP2

Family: Poly ADP-ribose polymerases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 583 14q11.2-q12 PARP2 poly(ADP-ribose) polymerase 2
Mouse - 559 14 C1 Parp2 poly (ADP-ribose) polymerase family, member 2
Rat - 558 15p14 Parp2 poly (ADP-ribose) polymerase 2
Previous and Unofficial Names
poly (ADP-ribose) polymerase family, member 2 | poly (ADP-ribose) polymerase family | ADPRTL2 | poly (ADP-ribose) polymerase 2
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Structure of PARP2 catalytic domain bound to inhibitor BMN 673 (talazoparib)
Ligand:  talazoparib
Resolution:  2.5Å
Species:  Human
References:  1
Image of receptor 3D structure from RCSB PDB
Description:  Structure of PARP2 catalytic domain bound to an isoindolinone inhibitor
Ligand:  compound 10b [PMID: 26222319]
Resolution:  1.65Å
Species:  Human
References:  5
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 10b [PMID: 26222319] Hs Inhibition 6.9 pKd 5
pKd 6.9 (Kd 1.25x10-7 M) [5]
olaparib Hs Inhibition 9.0 pIC50 2,4
pIC50 9.0 (IC50 1x10-9 M) [2,4]
Description: Assayed using PARP-2 isolated from HeLa cells, in a scintillation proximity ELISA.
niraparib Hs Binding 8.7 pIC50 3
pIC50 8.7 (IC50 2.1x10-9 M) [3]
talazoparib Hs Inhibition - - 1


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1. Aoyagi-Scharber M, Gardberg AS, Yip BK, Wang B, Shen Y, Fitzpatrick PA. (2014) Structural basis for the inhibition of poly(ADP-ribose) polymerases 1 and 2 by BMN 673, a potent inhibitor derived from dihydropyridophthalazinone. Acta Crystallogr F Struct Biol Commun, 70 (Pt 9): 1143-9. [PMID:25195882]

2. Dillon KJ, Smith GC, Martin NM. (2003) A FlashPlate assay for the identification of PARP-1 inhibitors. J Biomol Screen, 8 (3): 347-52. [PMID:12857389]

3. Jones P, Altamura S, Boueres J, Ferrigno F, Fonsi M, Giomini C, Lamartina S, Monteagudo E, Ontoria JM, Orsale MV et al.. (2009) Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J. Med. Chem., 52 (22): 7170-85. [PMID:19873981]

4. Menear KA, Adcock C, Boulter R, Cockcroft XL, Copsey L, Cranston A, Dillon KJ, Drzewiecki J, Garman S, Gomez S et al.. (2008) 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. J. Med. Chem., 51 (20): 6581-91. [PMID:18800822]

5. Papeo G, Posteri H, Borghi D, Busel AA, Caprera F, Casale E, Ciomei M, Cirla A, Corti E, D'Anello M et al.. (2015) Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy. J. Med. Chem., 58 (17): 6875-98. [PMID:26222319]

How to cite this page

Poly ADP-ribose polymerases: poly(ADP-ribose) polymerase 2. Last modified on 28/11/2018. Accessed on 20/11/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2772.