Top ▲ Isocitrate dehydrogenases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Isocitrate dehydrogenase (IDH) enzymes are crucial components of the central cellular metabolic pathway, the Krebs cycle. The enzymes catalyze the oxidative decarboxylation of isocitrate to produce α-ketoglutarate and carbon dioxide.


isocitrate dehydrogenase (NADP(+)) 1 / IDH1 C Show summary » More detailed page

isocitrate dehydrogenase (NADP(+)) 2 / IDH2 C Show summary » More detailed page


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How to cite this family page

Database page citation: Isocitrate dehydrogenases. Accessed on 29/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.