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Fc epsilon receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The type I high affinity IgE receptor (FCεRI) is crucial for the production of allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The FCεRII has a lower affinity for IgE.

Receptors

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FCεR1α (Fc fragment of IgE receptor Ia) Show summary » More detailed page go icon to follow link

FCεR1β (membrane spanning 4-domains A2) Show summary » More detailed page go icon to follow link

FCεR1γ (Fc fragment of IgE receptor Ig) Show summary » More detailed page go icon to follow link

FCεRII (Fc fragment of IgE receptor II) Show summary » More detailed page go icon to follow link

How to cite this family page

Database page citation:

Fc epsilon receptors. Accessed on 22/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=946.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Catalytic receptors. Br J Pharmacol. 176 Suppl 1: S247-S296.