Fc epsilon receptors

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Fc epsilon receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The type I high affinity IgE receptor (FCεRI) is crucial for the production of allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The FCεRII has a lower affinity for IgE.

Receptors

FCεR1α (Fc fragment of IgE receptor Ia) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2933
Nomenclature	Fc fragment of IgE receptor Ia
Common abbreviation	FCεR1α
Previous and unofficial names	Fc receptor, IgE, high affinity I, alpha polypeptide \| Fc receptor
Genes	FCER1A (Hs), Fcer1a (Mm), Fcer1a (Rn)
Ensembl ID	ENSG00000179639 (Hs), ENSMUSG00000005339 (Mm), ENSRNOG00000009177 (Rn)
UniProtKB AC	P12319 (Hs), P20489 (Mm), P12371 (Rn)

FCεR1β (membrane spanning 4-domains A2) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2936
Nomenclature	membrane spanning 4-domains A2
Common abbreviation	FCεR1β
Previous and unofficial names	membrane-spanning 4-domains, subfamily A, member 2 \| membrane-spanning 4-domains \| APY \| FCεR1β \| FCεRIβ \| IGEL \| IGER
Genes	MS4A2 (Hs), Ms4a2 (Mm), Ms4a2 (Rn)
Ensembl ID	ENSG00000149534 (Hs), ENSMUSG00000024680 (Mm), ENSRNOG00000020993 (Rn)
UniProtKB AC	Q01362 (Hs), P20490 (Mm), P13386 (Rn)

FCεR1γ (Fc fragment of IgE receptor Ig) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2934
Nomenclature	Fc fragment of IgE receptor Ig
Common abbreviation	FCεR1γ
Previous and unofficial names	Fc receptor, IgE, high affinity I, gamma polypeptide \| Fc receptor \| Fc epsilon receptor Ig \| high affinity I, receptor for Fc fragment of IgE \| Ly-50
Genes	FCER1G (Hs), Fcer1g (Mm), Fcer1g (Rn)
Ensembl ID	ENSG00000158869 (Hs), ENSMUSG00000058715 (Mm), ENSRNOG00000024159 (Rn)
UniProtKB AC	P30273 (Hs), P20491 (Mm), P20411 (Rn)

FCεRII (Fc fragment of IgE receptor II) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2935
Nomenclature	Fc fragment of IgE receptor II
Common abbreviation	FCεRII
Previous and unofficial names	Fc receptor, IgE, low affinity II, alpha polypeptide \| Fc receptor \| CD23 \| Fc epsilon RII \| FcεRII
Genes	FCER2 (Hs), Fcer2a (Mm), Fcer2 (Rn)
Ensembl ID	ENSG00000104921 (Hs), ENSMUSG00000005540 (Mm), ENSRNOG00000001005 (Rn)
UniProtKB AC	P06734 (Hs), P20693 (Mm)

How to cite this family page

Database page citation:

Fc epsilon receptors. Accessed on 09/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=946.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.