Top ▲

Orai channels C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

Orai channels are pore forming proteins which underlie calcium release-activated calcium (CRAC) channels. When calcium is lost from the endoplasmic reticulum, they form complexes with STIM (stromal interaction molecule) proteins to trigger calcium entry following store depletion [1].

Channels and Subunits

Click here for help

Orai1 C Show summary » More detailed page go icon to follow link

Orai2 C Show summary » More detailed page go icon to follow link

Orai3 C Show summary » More detailed page go icon to follow link

Comments

Click here for help

Show »

Further reading

Click here for help

Show »

References

Click here for help

Show »

How to cite this family page

Database page citation:

Orai channels. Accessed on 17/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=977.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Ion channels. Br J Pharmacol. 176 Issue S1: S142-228.