Orai channels

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Channels and Subunits

Orai1 Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2964
Nomenclature	Orai1
Genes	ORAI1 (Hs), Orai1 (Mm), Orai1 (Rn)
Ensembl ID	ENSG00000276045 (Hs), ENSMUSG00000049686 (Mm)
UniProtKB AC	Q96D31 (Hs), Q8BWG9 (Mm), Q5M848 (Rn)
Comment	ORAI1 is the gene that encodes the prototypical CRAC store-operated Ca2+ entry (SOCE) channel. CRAC channels are activated by depletion of Ca²⁺ in the endop[lasmic reticulum that results from antigen-induced activation of a range of immunoreceptors/ (including TCRs, BCRs, Fcγ and Fcε receptors, chemokine GPCRs and some innate pattern-recognition receptors).

Orai2 Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2965
Nomenclature	Orai2
Previous and unofficial names	CAP-binding protein complex interacting protein 2 \| CBCIP2 \| TMEM142B
Genes	ORAI2 (Hs), Orai2 (Mm), Orai2 (Rn)
Ensembl ID	ENSG00000160991 (Hs), ENSRNOG00000001427 (Rn)
UniProtKB AC	Q96SN7 (Hs), Q8BH10 (Mm)

Orai3 Show summary »« Hide summary More detailed page go icon to follow link

How to cite this family page

Database page citation:

Orai channels. Accessed on 23/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=977.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Ion channels. Br J Pharmacol. 176 Issue S1: S142-228.