BTB (POZ) domain containing TFs: Introduction

The BTB/POZ transcription factor family has four members, BCL6, Kaiso (ZBTB33), HIC1, and PLZF (ZBTB16). They all also belong to the much larger C2H2-type zinc finger transcription factor family.

BCL6 is a molecular target for the development of novel drugs for the treatment of autoimmune diseases and B cell lymphomas. The Orphanet entry for BCL6 (ORPHA 158372) contains details of the genetic abnormalities in BCL6 that are associated with B cell and follicular lymphomas.

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To cite this family introduction, please use the following:

BTB (POZ) domain containing TFs, introduction. Last modified on 03/10/2017. Accessed on 21/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=973.