pridopidine [Ligand Id: 13833] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL596802 (ACR-16, ACR16, FR-310826, FR310826, Huntexil, Pridopidina, Pridopidine)
  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Displacement of [3H]spiperone from human dopamine D2 receptor at low affinity state expressed in HEK293 cells B 4.76 pKi 17550 nM Ki J Med Chem (2010) 53: 2510-2520 [PMID:20155917]
ChEMBL Binding affinity to dopamine D2 (low) receptor (unknown origin) B 4.76 pKi 17500 nM Ki J Med Chem (2020) 63: 15187-15217 [PMID:33111525]
ChEMBL Binding affinity to D2R receptor (unknown origin) B 5 pKi 10000 nM Ki Bioorg Med Chem (2022) 73: 117032-117032 [PMID:36202063]
ChEMBL Displacement of [3H]spiperone from human dopamine D2 receptor at high affinity state expressed in HEK293 cells B 5.12 pKi 7521 nM Ki J Med Chem (2010) 53: 2510-2520 [PMID:20155917]
ChEMBL Binding affinity to dopamine D2 (high) receptor (unknown origin) B 5.12 pKi 7500 nM Ki J Med Chem (2020) 63: 15187-15217 [PMID:33111525]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL Binding affinity to sigma 1 receptor (unknown origin) assessed as inhibition constant B 7.09 pKi 82 nM Ki Eur J Med Chem (2023) 249: 115163-115163 [PMID:36716640]
ChEMBL Inhibition of [3H](+)-pentazocine binding to human sigma1 receptor expressed in HEK293 cells by liquid scintillation spectrometry B 7.09 pKi 81.7 nM Ki J Med Chem (2020) 63: 15187-15217 [PMID:33111525]
GtoPdb Displacement of [3H](+)-pentazocine binding to human sigma1 receptor expressed in HEK293 cells, determined by liquid scintillation spectrometry - 7.09 pKi 81.7 nM Ki J Med Chem (2020) 63: 15187-15217 [PMID:33111525]
ChEMBL Binding affinity to sigma 1 receptor (unknown origin) B 7.77 pKi 17 nM Ki Bioorg Med Chem (2022) 73: 117032-117032 [PMID:36202063]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]