AD015 [Ligand Id: 13835] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL315037
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
GtoPdb Inhibition of nACE - 7.72 pIC50 19 nM IC50 J Med Chem (2025) 68: 7720-7736 [PMID:40168649]
ChEMBL Inhibition of human glycosylated N-terminal catalytic ACE domain using Cbz-Phe-His-Leu substrate by fluorogenic end point activity assay B 7.72 pIC50 19 nM IC50 J Med Chem (2025) 68: 7720-7736 [PMID:40168649]
ChEMBL Inhibition of human glycosylated C-terminal catalytic ACE domain using Cbz-Phe-His-Leu substrate by fluorogenic end point activity assay B 9 pIC50 1 nM IC50 J Med Chem (2025) 68: 7720-7736 [PMID:40168649]
GtoPdb Inhibition of cACE - 9.1 pIC50 0.8 nM IC50 J Med Chem (2025) 68: 7720-7736 [PMID:40168649]
Angiotensin-converting enzyme in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2625] [GtoPdb: 1613] [UniProtKB: P47820]
ChEMBL In vitro inhibition of rat angiotensin I converting enzyme B 8.17 pIC50 6.8 nM IC50 J Med Chem (1996) 39: 2594-2608 [PMID:8691458]
Neutral endopeptidase/Neprilysin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944] [GtoPdb: 1611] [UniProtKB: P08473]
ChEMBL Inhibition of human NEP ectodomain using MCA-RPPGFSAFK-(Dnp)-OH peptide as substrate by continuous activity assay B 8.05 pIC50 9 nM IC50 J Med Chem (2025) 68: 7720-7736 [PMID:40168649]
GtoPdb - - 8.05 pIC50 9 nM IC50 J Med Chem (2025) 68: 7720-7736 [PMID:40168649]
Neprilysin in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3768] [UniProtKB: P08049]
ChEMBL In vitro inhibition of neutral endopeptidase B 7.9 pIC50 12.5 nM IC50 J Med Chem (1996) 39: 2594-2608 [PMID:8691458]

ChEMBL data shown on this page come from version 37:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]