AD015 [Ligand Id: 13835] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL315037 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme in Human [GtoPdb: 1613] [UniProtKB: P12821] | ||||||||
| GtoPdb | Inhibition of nACE | - | 7.72 | pIC50 | 19 | nM | IC50 | J Med Chem (2025) : [PMID:40168649] |
| GtoPdb | Inhibition of cACE | - | 9.1 | pIC50 | 0.8 | nM | IC50 | J Med Chem (2025) : [PMID:40168649] |
| Angiotensin-converting enzyme in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2625] [GtoPdb: 1613] [UniProtKB: P47820] | ||||||||
| ChEMBL | In vitro inhibition of rat angiotensin I converting enzyme | B | 8.17 | pIC50 | 6.8 | nM | IC50 | J Med Chem (1996) 39: 2594-2608 [PMID:8691458] |
| Neprilysin in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3768] [UniProtKB: P08049] | ||||||||
| ChEMBL | In vitro inhibition of neutral endopeptidase | B | 7.9 | pIC50 | 12.5 | nM | IC50 | J Med Chem (1996) 39: 2594-2608 [PMID:8691458] |
| Neutral endopeptidase in Human [GtoPdb: 1611] [UniProtKB: P08473] | ||||||||
| GtoPdb | - | - | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2025) : [PMID:40168649] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
