imidazole ketone erastin [Ligand Id: 13930] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3629671 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cystine/glutamate transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075149] [GtoPdb: 902] [UniProtKB: Q9UPY5] | ||||||||
| GtoPdb | Measuring inhibition of glutamate release from astrocytoma cells, which is indicative of inhibition of the system xc- cystine/glutamate transporter | - | 7.52 | pIC50 | 30 | nM | IC50 | Cell Chem Biol (2019) 26: 623-633.e9 [PMID:30799221] |
| ChEMBL | Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometry | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 4787-4792 [PMID:26231156] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
