ENPP1 inhibitor 29f [Ligand Id: 13938] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL5413273 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ectonucleotide pyrophosphatase/phosphodiesterase 1/Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5925] [GtoPdb: 3312] [UniProtKB: P22413] | ||||||||
| ChEMBL | Inhibition of ENPP1 in human MDA-MB-231 cells using p-NPh-5TMP as substrate at pH 8.5 measured after 60 mins | B | 5.34 | pIC50 | 4561 | nM | IC50 | J Med Chem (2025) 68: 5856-5873 [PMID:39973889] |
| ChEMBL | Inhibition of recombinant human ENPP1 transfected in HEK293T cells using cGAMP as substrate at pH 7.5 measured after 3.5 hrs by luminescence based AMP-glo assay | B | 5.86 | pIC50 | 1377 | nM | IC50 | J Med Chem (2025) 68: 5856-5873 [PMID:39973889] |
| ChEMBL | Inhibition of ENPP1 in human MDA-MB-231 cells using p-NPh-5TMP as substrate at pH 9.5 measured after 60 mins | B | 6.25 | pIC50 | 556 | nM | IC50 | J Med Chem (2025) 68: 5856-5873 [PMID:39973889] |
| ChEMBL | Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by substrate addition and measured after 90 mins by AMP-Glo reagent based luminescence plate reader analysis | B | 7.17 | pIC50 | 68 | nM | IC50 | J Med Chem (2023) 66: 15141-15170 [PMID:37963811] |
| ChEMBL | Inhibition of ENPP1 (unknown origin) | B | 7.17 | pIC50 | 68 | nM | IC50 | Eur J Med Chem (2024) 268: 116286-116286 [PMID:38432057] |
| GtoPdb | Inhibition of cGAMP hydrolysis | - | 7.17 | pIC50 | 68 | nM | IC50 | J Med Chem (2023) 66: 15141-15170 [PMID:37963811] |
ChEMBL data shown on this page come from version 37:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
