GLX351322 [Ligand Id: 14283] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL5399030 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cytochrome b-245 beta chain/Cytochrome b-245 heavy chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287627] [GtoPdb: 3002] [UniProtKB: P04839] | ||||||||
| ChEMBL | Inhibition of human NOX2 in PBMC cells | B | 4.4 | pIC50 | 40000 | nM | IC50 | J Med Chem (2023) 66: 11632-11655 [PMID:37650225] |
| NADPH oxidase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250375] [GtoPdb: 3004] [UniProtKB: Q9NPH5] | ||||||||
| GtoPdb | - | - | 5.3 | pIC50 | 5000 | nM | IC50 | Free Radic Res (2015) 49: 1308-18 [PMID:26118714] |
| ChEMBL | Inhibition of human NOX4 in T-REx-293 cells | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2023) 66: 11632-11655 [PMID:37650225] |
| NADPH oxidase 1 in Human [GtoPdb: 3001] [UniProtKB: Q9Y5S8] | ||||||||
| GtoPdb | - | - | 4.4 | pIC50 | 40000 | nM | IC50 | Free Radic Res (2015) 49: 1308-18 [PMID:26118714] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
