mitucapistat [Ligand Id: 14359] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL475920 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| calpain 1/Calpain-1 catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3891] [GtoPdb: 2336] [UniProtKB: P07384] | ||||||||
| ChEMBL | Inhibition of human erythrocyte mu-calpain | B | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5174-5177 [PMID:18789863] |
| GtoPdb | Inhibition of μ-type calpain from human erythrocytes | - | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem (2005) 13: 4473-84 [PMID:15921914] |
| Calpain-2 catalytic subunit in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4143] [UniProtKB: P43367] | ||||||||
| ChEMBL | Inhibition of pig kidney m-calpain | B | 7 | pIC50 | 99 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5174-5177 [PMID:18789863] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
