psilocybin [Ligand Id: 14389] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL194378 (COMP-360, COMP360, CY 39, CY-39, CY39, Indocybin, Psilocibina, Psilocybin, Psilocybine, Teonanacatl) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT2A receptor/5-hydroxytryptamine receptor 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | Inhibition of 5-HT2AR (unknown origin ) assessed as inhibition constant | B | 5 | pKi | >10000 | nM | Ki | RSC Med Chem (2024) 15: 998-1002 [PMID:38516602] |
| ChEMBL | Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay | F | 5.46 | pEC50 | 3475 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 4555-4559 [PMID:16061378] |
| 5-HT2B receptor/5-hydroxytryptamine receptor 2B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| ChEMBL | Inhibition of 5-HT2BR (unknown origin ) assessed as inhibition constant | B | 7.01 | pKi | 98.7 | nM | Ki | RSC Med Chem (2024) 15: 998-1002 [PMID:38516602] |
| ChEMBL | Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay | F | 7.13 | pEC50 | 74 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 4555-4559 [PMID:16061378] |
| 5-HT2C receptor/5-hydroxytryptamine receptor 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determined by phosphoinositide hydrolysis assay | F | 6.3 | pEC50 | 506 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 4555-4559 [PMID:16061378] |
| GtoPdb | Dtermined in an IP3 accumulation assay | - | 7.13 | pEC50 | 74 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 4555-9 [PMID:16061378] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
