ligustilide [Ligand Id: 14479] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL481246
  • TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
  • TRPA1/Transient receptor potential cation channel subfamily A member 1 in Mouse [ChEMBL: CHEMBL1075310] [GtoPdb: 485] [UniProtKB: Q8BLA8]
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  • mesenchyme homeobox 1 in Human [GtoPdb: 3348] [UniProtKB: P50221]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
ChEMBL Agonist activity at TRPA1 (unknown origin) B 4.36 pEC50 44000 nM EC50 Bioorg Med Chem Lett (2013) 23: 5614-5618 [PMID:23993334]
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075310] [GtoPdb: 485] [UniProtKB: Q8BLA8]
ChEMBL Antagonist activity at mouse TRPA1 expressed in HEK293F cells as increase in Ca2+ influx by FLIPR calcium assay B 4.36 pEC50 44000 nM EC50 Eur J Med Chem (2023) 257: 115392-115392 [PMID:37269667]
mesenchyme homeobox 1 in Human [GtoPdb: 3348] [UniProtKB: P50221]
GtoPdb Determined by SPR, binding of ligand to immobilised MEOX1 protein - 5.21 pKd 6200 nM Kd BJP (2026) :

ChEMBL data shown on this page come from version 37:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]