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rovalpituzumab tesirine   Click here for help

GtoPdb Ligand ID: 10561

Synonyms: Rova-T | SC0001-SCX
Compound class: Antibody
Comment: Rovalpituzumab tesirine is an antibody-drug conjugate (ADC) that was designed to exploit the expression of the NOTCH ligand DLL3 on certain tumours for anti-cancer efficacy [1]. It is a humanized anti-DLL3 monoclonal that is linked to a pyrrolobenzodiazepine dimer toxin called tesirine (or D6.5; PubChem CID 73672523). Once the ADC is internalized, its D6.5 payload is released and causes lethal DNA damage in the target cells.
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
10141 rovalpituzumab tesirine
Synonyms Click here for help
Rova-T | SC0001-SCX
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 569
Other databases
GtoPdb PubChem SID 404859008
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