bintrafusp alfa

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Ligands
bintrafusp alfa

GtoPdb Ligand ID: 11376

Synonyms: M7824 | MSB0011359C

Compound class: Antibody

Comment: Bintrafusp alfa (M7824) is an investigational bifunctional fusion protein that combines two TGFβ 'trap' domains (derived from the extracellular domain of TGFBR2) that are linked to each of the C-terminal domain of the heavy chains of an anti-PD-L1 IgG1 monoclonal (mAb) [1,3]. The antibody component is similar to the anti-PD-L1 mAb avelumab and similarly, bintrafusp alfa was developed as a cancer immunotherapeutic [5]. Based on evidence that both the TGFβ pathway and the PD-PD-L1/PD-1 immune checkpoint are associated with tumour immune evasion, simultaneous targeting of these pathways was predicted to control tumour growth by restoring and enhancing anti-tumour immune responses [2,4].

Bintrafusp alfa is similar in structure and function to the approved drug retlirafusp alfa.

Immunopharmacology Comments
Simultaneous targeting of the PD-1/PD-L1 and TGFβ signalling pathways was proposed as a mechanism to reverse local immunosuppressive signals and to restore and enhance anti-tumour immune responses in the tumour microenvironment [2,4].

Immunopharmacology Comments

Simultaneous targeting of the PD-1/PD-L1 and TGFβ signalling pathways was proposed as a mechanism to reverse local immunosuppressive signals and to restore and enhance anti-tumour immune responses in the tumour microenvironment [2,4].