bezlotoxumab   Click here for help

GtoPdb Ligand ID: 13334

Synonyms: BLA 761046 | MBL-CDB1 | MDX-1388 | Zinplava®
Approved drug
bezlotoxumab is an approved drug (FDA (2016), EMA (2017), Japan (2017))
Compound class: Antibody
Comment: Bezlotoxumab is a fully human IgG1 monoclonal antibody that binds to Clostridioides difficile toxin B [1]. It does not have inherent antibacterial activity but prevents binding of toxin B to colonic cells and reducing colonic cell inflammation. It is used to reduce the recurrence of C. difficile infection (CDI) in patients receiving antibacterial treatment for CDI.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
Classification Click here for help
Compound class Antibody
Approved drug? Yes. FDA (2016)  |  EMA (2017)  |  Japan (2017)
International Nonproprietary Names Click here for help
INN number INN
9608 bezlotoxumab
Synonyms Click here for help
BLA 761046 | MBL-CDB1 | MDX-1388 | Zinplava®
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Bezlotoxumab, Zinplava
IMGT/mAb-DB 411
Other databases
CAS Registry No. 1246264-45-8 (source: Scifinder)
ChEMBL Ligand CHEMBL2108670
DrugBank Ligand DB13140
DrugCentral Ligand 5186
GtoPdb PubChem SID 496703304
Search PubMed clinical trials bezlotoxumab
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Wikipedia Bezlotoxumab