raxibacumab

Home
Ligands
raxibacumab

GtoPdb Ligand ID: 13344

Synonyms: Abthrax | PAmAb

raxibacumab is an approved drug (FDA (2012))

Comment: Raxibacumab is a human IgG1 monoclonal antibody targeting the protective antigen (PA) component of the Bacillus anthracis toxin [2]. It has clinical approval for the prophylaxis and treatment of inhaled anthrax.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

References
1. Migone TS, Subramanian GM, Zhong J, Healey LM, Corey A, Devalaraja M, Lo L, Ullrich S, Zimmerman J, Chen A et al.. (2009) Raxibacumab for the treatment of inhalational anthrax. N Engl J Med, 361 (2): 135-44. [PMID:19587338]
2. Subramanian GM, Cronin PW, Poley G, Weinstein A, Stoughton SM, Zhong J, Ou Y, Zmuda JF, Osborn BL, Freimuth WW. (2005) A phase 1 study of PAmAb, a fully human monoclonal antibody against Bacillus anthracis protective antigen, in healthy volunteers. Clin Infect Dis, 41 (1): 12-20. [PMID:15937757]

References

1. Migone TS, Subramanian GM, Zhong J, Healey LM, Corey A, Devalaraja M, Lo L, Ullrich S, Zimmerman J, Chen A et al.. (2009)
Raxibacumab for the treatment of inhalational anthrax.
N Engl J Med, 361 (2): 135-44. [PMID:19587338]

2. Subramanian GM, Cronin PW, Poley G, Weinstein A, Stoughton SM, Zhong J, Ou Y, Zmuda JF, Osborn BL, Freimuth WW. (2005)
A phase 1 study of PAmAb, a fully human monoclonal antibody against Bacillus anthracis protective antigen, in healthy volunteers.
Clin Infect Dis, 41 (1): 12-20. [PMID:15937757]