gremubamab

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gremubamab

GtoPdb Ligand ID: 13374

Synonyms: MEDI3902

Comment: Gremubamab (MEDI3902) is a bivalent, bispecific monoclonal antibody [2]. It is under clinical development as a treatment for nosocomial pneumonia caused by Pseudomonas aeruginosa.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

References
1. Chastre J, François B, Bourgeois M, Komnos A, Ferrer R, Rahav G, De Schryver N, Lepape A, Koksal I, Luyt CE et al.. (2022) Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial. Crit Care, 26 (1): 355. [PMID:36380312]
2. DiGiandomenico A, Keller AE, Gao C, Rainey GJ, Warrener P, Camara MM, Bonnell J, Fleming R, Bezabeh B, Dimasi N et al.. (2014) A multifunctional bispecific antibody protects against Pseudomonas aeruginosa. Sci Transl Med, 6 (262): 262ra155. [PMID:25391481]

References

1. Chastre J, François B, Bourgeois M, Komnos A, Ferrer R, Rahav G, De Schryver N, Lepape A, Koksal I, Luyt CE et al.. (2022)
Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial.
Crit Care, 26 (1): 355. [PMID:36380312]

2. DiGiandomenico A, Keller AE, Gao C, Rainey GJ, Warrener P, Camara MM, Bonnell J, Fleming R, Bezabeh B, Dimasi N et al.. (2014)
A multifunctional bispecific antibody protects against Pseudomonas aeruginosa.
Sci Transl Med, 6 (262): 262ra155. [PMID:25391481]